肝細胞でも同じか。
移植後に増える細胞
造血幹細胞
肝細胞
表皮細胞
上記以外にあるのかね。
Friday, February 13, 2015
Sunday, February 8, 2015
奇形腫の成熟，未熟と良性，悪性の関係 ---専門家よりのご教授---
奇形腫の成熟，未熟と良性，悪性の関係，teratoma with malignant transformationの組織発生に関して、専門家よりご教授頂きました。
ヒトの奇形腫では，性別と年齢で状況が全く異なります．すなわち，女性の卵巣の未熟奇形腫は悪
性，成熟奇形腫は良性ですが，男性の精巣の場合は，小児の奇形腫は成熟，未熟にか
かわらず良性，成人の奇形腫は成熟，未熟にかかわらず悪性，というのが一般的な理
解だと思います．この論文の書き方は異なるように思われます．また，teratoma
with malignant transformationは卵巣の成熟奇形腫から出る扁平上皮癌がよくしら
れているものですが，これは奇形腫の未熟性とは無関係なものです．
Friday, February 6, 2015
Mesenchymal Stem Cells from Bone Marrow Enhance Neovascularization and Stromal Cell Proliferation
Mesenchymal Stem Cells from Bone Marrow Enhance Neovascularization and Stromal Cell Proliferation in Rat Ischemic Limb in the Early Phase after Implantation.
Sayaka USUI, Yoshitaka ISO, Masahiro SASAI, Takuya MIZUKAMI, Chisato SATO, Masaaki KURATA, Akihiro UMEZAWA, Seiji SHIODA, Hiroshi SUZUKI
In the present study we investigated the efficacy of MSC implantation into a hindlimb ischemia model over a short-term period to elucidate the effects conferred within the early phase after treatment. MSCs from rats expressing green fluorescence protein (GFP) were injected into rat ischemic limbs. Laser Doppler perfusion imaging revealed significantly higher blood perfusion recovery in the MSC group than in the control group on days 3 and 7 after the treatment. The capillary/muscle fiber ratio in ischemic muscle was also significantly higher in the MSC group than in the controls in a histological study. In spite of these benefits, we found no evident engraftment of the GFP-positive cells, and instead, the MSC treatment induced a proliferation of resident stromal cells in the perivascular area of the ischemic muscle, some of which produced vascular endothelial growth factor. The present study suggested that MSC therapy promotes neovascularization even in the early phase, both directly through endothelial proliferation and indirectly through activation of the resident stromal cells.
https://www.jstage.jst.go.jp/article/sujms/26/2/26_121/_pdf
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