o Novel markers for mesenchymal stem cell identification to enhance isolation and purification and to facilitate ex vivo stem cell expansion systems.
学会で間葉系幹細胞マーカの話を聞いた。
CD106 (VCAM1)がヒトでいいという再生研の話。このマーカを有する細胞は増殖がいいとのこと。
別のグループがヒトでCD133、CD271(NGFR, trk, p75, low-affinity nerve growth factor receptor)がいいとのこと。
その同じグループがマウスでは、CD140a (PDGFRalpha), Sca-1がいいといういう話。
間葉系幹細胞マーカの話は、他の幹細胞に比べ、明らかに遅れている。その理由は、in vitro, in vivoのアッセイが標準化（均てん化）されていないためである。それは兎も角、しっかりとした研究グループからこのような発表があることは極めて好ましい。是非、確認してみたい。
Research areas of interest:
o Basic mesenchymal stem cell biology.
o Studies defining the lineage relationship between mesenchymal stem cells
and other stem cells.
o Novel markers for mesenchymal stem cell identification to enhance isolation
and purification and to facilitate ex vivo stem cell expansion systems.
o Refinement of cellular culture systems and elucidation of the molecular
events that permit ex vivo expansion of mesenchymal stem cells.
o Identification and characterization of functional, molecular regulators of
mesenchymal stem cell self-renewal and commitment.
o In vivo and in vitro assay systems for human mesenchymal stem cells.
o Role of growth factors, cytokines, receptors, transmembrane signaling,
marrow microenvironment, and adhesive proteins in mesenchymal stem cell
interactions and hematopoiesis.
o Identification and characterization of mechanisms by which mesenchymal stem
cells increase stem cell engraftment.
o Histocompatibility and allo-interactions, mechanism of induction of
transplant tolerance, minimizing the graft vs. host effect and graft
rejection for organ and cellular transplants of heart, lung, or blood
tissues.
o Studies on the biology of mesenchymal stem cells in aging including changes
in potential, population dynamics, mobilization, and interaction with the
aging environment.
o Basic research studies to develop future mesenchymal stem cell therapies to
correct genetic diseases or for repair or regeneration of tissue or organ
damage.
o Basic research studies to develop future gene therapy approaches using
mesenchymal stem cells as targets for gene insertion and long-term expression
of normal genes using viral and non-viral approaches to gene transduction.
