糖 modification of snail in E-M transition

CHO (carbohydrate)--- Yonsei Univ

Inhibitor of O-GlcNAccase: NAG-thiazoline (NTZ)
O-GlcNAc transferase: OGT

O-GlcNAc on p53 in Yang, WH, et al., Nat Cell Biol 2006. O-GlcNAc-modified p53 is stabilized.

NFkB p65 O-GlcNAc modification.
O-GlcNAc protein modification in cancer cells

GFAT increases
UDP-GlcNAc

Active snail repress E-cadherin via binding to its recognition sequence in E-cad promoter (Nat Cell Biol, 6:931, 2004). O-Glcacylated snail.

GSK3beta is also involved in snail phosphorilation (by Park). Snail by Trcp
snail modification by OGT can promote repression of E-cadherin, and increase EMT.

Phosphorylation (EMT repression) and glycosylation (EMT promotion) has differential roles in snail stability, i.e. EMT.