Neural crest regulatory network story --- by Dr Marianne Bronner-Fraser---

Neural crest enhancer cascade

Neural crest-derived cells differentiate into melanocytes, autonomous nerve, calvaria bone, and teeth.　頭蓋の間葉系幹細胞と骨髄間質細胞は、神経堤由来ってこと。

I. Cytokines: Wnt, BMP, FGF.

II. Border-specifier gene: Msx1/2, Pax3/7, Zic

III. Neural crest specifier gene: Slug/snail, FoxD3, SoxE

siRNAでknock downさせて、ネットワークを決めていた。