OAの患者から得た軟骨細胞は、特徴的な体細胞変化を起こしている。

OA由来の軟骨細胞は、染色体の7番だかがトリソミーになっているらしい。一定の傾向があり、染色体の7番が35%にトリソミーとして検出された。この話は驚きではないか。

Osteoarthritis Cartilage. 2004 Dec;12(12):982-5.
FISH analysis revealed that 46% of OA patients had numerical abnormalities of chromosomes 7, X or Y. An extra chromosome 7 (trisomy 7) was present in 35% of patients with chromosomal aberrations. All males with OA lost the Y chromosome while 15% of the women had loss of one chromosome X (monosomy X). Trisomy 7 was associated with hip OA (p=0.019) and advanced OA according to the Kellgren and Lawrence classification (p=0.05). None of the 11 controls showed abnormalities in the chromosomes analyzed.

Cancer Genet Cytogenet. 2001 Nov;131(1):19-24.
Analysis of the distribution and frequency of trisomy 7 in vivo in synovia from patients with osteoarthritis and pigmented villonodular synovitis.
Osteoarthritis (OA) and pigmented villonodular synovitis (PVNS) are disorders associated with trisomy 7.