ER stress --- WFS1

Homeostatic output

WFS1 in ER membrene suppresses ER stress, and promotes insulin production.
Mutation in the WFS1 gene causes type II DM, and diabete insipidas. Psychiatric
How beta-cell death is caused by WFS1 mutation.

Type Ib DM

Chronic ER stress

Ire1
PERK
ATF6---Inverse correlation with WFS1 expression

WFS1 degraded ATF6 overactivation through ubiquitin incorporation. DIRECT interaction?

Specifier

HRD1
XBP1----WFS1
ATF4----WFS1
BiP
ero1

International registry of patients with Wolfram syndrome.
1.

AATF-AKT1: Apoptosis Antagonizing xxx targets AKT1. kinasing caskade